Since the inception of the Safe Motherhood Initiative (SMI) by WHO, UNFPA and World Bank in Nairobi, Kenya, in 1989, several intervention programs have been instituted by stakeholders at governmental and nongovernmental levels, nationally and internationally, to implement the initiative’s strategies to curb the high maternal morbidity and mortality rates in the developing countries of Sub-Saharan African and Asia. This quasi-experimental study had a sample size of 400 women, and the researcher used health talk, demonstration (of history taking, blood pressure, weight measurement to establish women’s health status, etc.), and role-play exercises to investigate the effects of health education intervention on the attitudes of women of reproductive age toward SMI components of antenatal family planning and PMTCT of HIV and AIDS in Eleme, Rivers State, Nigeria. Findings revealed the intervention had a significant effect on the attitudes of women in the intervention group, who had a higher mean gain difference (.6250, 1.2350, and .2775) than did the control group (.4150, 1.0775, and .0325) in the posttest scores, F1 (397 = 70.077, p = .000, p < .05). However, statistically, there was no significant difference on attitudes toward SMI between the age groups of the women, F3 (394 = .079, p = .971, p > .05).